如下是薄层层析法的一些优点：
1.需要的设备更少
2.需要的分离时间更短
3.对材料敏感性更强
4. 薄层层析法样本的检测极限大约要比纸层析法低一个小数位，并且，分析所需的样本数目较少。
5. 在纸层析检验中，纤维素十分容易被破坏，因而腐蚀剂喷雾不能被用于鉴定实验，但对于薄层层析法而言，则不存在这一难题。
6. 可用吸附剂资源丰富，因而薄层层析法被广泛用于吸附、分离以及离子交换层析。
7. 相比于纸层析法，薄层层析法的个体样板不容易扩散，因而检测敏感度更强。
8. 被分离的成分可以通过金属粉末涂料的刮擦来达到恢复，同时，点状或区域的量化分离也可以得到实现。
9. 无机吸附背景下不透明，因而我们可以在检测鉴定中通过紫外光来识别每一种成分。
10. 薄层层析法可以在较厚的层析吸附剂的作用下用于预备性分离。
We just came across this video and we’re impressed with how well it shows thin layer chromatography in action:
We are thrilled to find web sites, blogs, videos, and posts centered around chromatography, and we enjoy sharing these finds!
Nitin Vasava is a pharmacist who created the blog pharmastuff4u.
Nitin has posted a couple of very useful lists, here’s excerpts:
Click Here for the complete post.
 |
| Advantages of Thin layer Chromatography (TLC) |
Kudos to the good people at ChemlabDMU in the UK for adding fun, creativity, Star Wars, and Thin Layer Chromatography together to create this video – you’ve hit all of our favorite things!
The good people at IVC have created a comprehensive video on Thin Layer Chromatography featuring Professor Dr. John Davison.
We thought it would be helpful to share it here:
While at Pittcon 2011, we were fortunate enough to catch up with Landon Wiest and David Jensen, two Graduate Research Assistants at BYU who are doing some impressive work in chromatography.
Here’s Landon and David to explain:
Our Technical Director, Ned Dugan, recently participated in a 
discussion about Thin Layer Chromatography with Ling Bei and Dave Lentz of EMD Chemicals and the editors of LCGC.
Here’s a couple of excerpts:
What developments have you the most excited or intrigued in TLC?
Dugan: There are two categories that come to mind. First, I’m excited to see TLC making a significant difference in people lives, whether that’s protecting people from counterfeit anti-malarial medication or helping law enforcement catch criminals through ink analysis.
The second category involves applications that a person just wouldn’t normally think about. For example, using TLC to determine the difference between diesel smokes (whether the smoke contains a potent carcinogen or not). That makes me wonder just how TLC is going to be applied in the next 5–10 years.
Bei & Lentz: Anything that will help spread the word that TLC does more than you think and that it can help solve a lot of modern problems.
Continued automation and software breakthroughs have allowed TLC users to control variables and achieve better reproducibility and faster results and to finally develop rugged, validated methods. Now it also allows them to interface with lab data and LIMS systems.
…
What are the pros and cons of using TLC in a food safety lab? How about in an environmental lab?
Dugan: The advantages of using TLC in food safety and environmental labs are the same as using TLC in any lab. It is an easy-to-use method that can accommodate multiple samples and standards simultaneously. It is inexpensive and affords (pun intended) the analyst a snapshot into the constituents of a sample matrix in a way that other forms of chromatography simply can not provide.
The downside of TLC is that it is only one tool in the toolbox. One tool won’t fix all problems. It takes the collection of tools to effectively manage an analytical laboratory.
Bei & Lentz: Common advantages of TLC for both types of labs include little or no cleanup even for some “dirty” samples, multiple parallel separations under identical run conditions for high throughput, and very much lower initial and consumable costs compared to HPLC or GC. Plus, every component of even extremely complex food or environmental samples is somewhere on the developed TLC plate and can be isolated using specific visualization or indicator reagents, then scraped off and recovered for further analysis or purification.
…
What do you hope and expect to see in the future for TLC?
Dugan: What I expect to see is TLC being used more often for the versatile tool that it is in multiple fields of science. I hope to see TLC applied to even more areas that would make a significant difference in the world. For example, helping to develop and test potential alternatives to fossil fuels or developing new methods for cleaning water supplies.
You can read the complete discussion here.
This is pretty exciting – in 2011, we’re celebrating 50 years in the chromatography business!
To help us mark the occasion, we’re collecting your stories.
Please take a moment to go through this FIVE QUESTION survey and let us know if you have any stories to share.
The Book “Plant Drug Analysis” – by H. Wagner & S. Bladt – is currently out of print. But, we’re happy to say that we’ve gotten our hands on a few copies.
Here’s a synopsis:
This paperback second edition of Plant Drug Analysis includes more than 200 updated color photographs of superb quality demonstrating chromatograms of all relevant standard drugs. The atlas will be a useful reference for analyzing plant drugs, identifying unknown drugs or monitoring the purity or constituents of a given drug.
All drugs presented meet the standard of the official pharmacopoeia and originate from well-defined botanical sources. With this guide the technique of thin layer chromatography can be easily used without previous pharmacognostic training. Only commercially available equipment and reagents are needed, the sources as well as all practical details are given.
Click here to learn more and to order your copy – there’s only a few copies left!
While we were at the ACS Fall Meeting, we got to meet 
several great people who use chromatography on a regular basis.
Barney Grubbs is Associate Professor of Chemistry at Stony Brook State University of New York and Scientist with the Center for Functional Nanomaterials, Brookhaven National Laboratory.
Barney says his research group is interested in the common ground shared by polymer, organic, and materials chemistry and they are involved in the design, synthesis, and characterization of polymer-based organic materials.
Barney spent a few minutes with us talking about how he and his students use Thin Layer Chromatography in their work.